Multi-layered regulation of intestinal antimicrobial defense

S. Mukherjee, S. Vaishnava, L. V. Hooper

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations


The gastrointestinal tract of mammals is heavily colonized with a complex and dynamic microbial community. To cope with this complex microbial challenge, multiple epithelial lineages, such as enterocytes and Paneth cells, elaborate a diverse repertoire of protein antibiotics. The gut antimicrobial arsenal encompasses multiple protein families, including defensins, cathelicidins, and C-type lectins. These antimicrobial peptides and proteins play a key role in protecting the host against pathogen challenge, and likely also function to limit invasion of indigenous microbes. It is becoming increasingly apparent that expression of mucosal antimicrobial defenses is tightly controlled. This occurs at multiple levels, including transcriptional regulation in response to bacterial cues, post-translational proteolytic processing, and bacterial regulation of Paneth cell degranulation. Impaired antimicrobial peptide expression has also been implicated in inflammatory bowel disease, underscoring the essential role of antimicrobial defenses in maintaining intestinal homeostasis.

Original languageEnglish (US)
Pages (from-to)3019-3027
Number of pages9
JournalCellular and Molecular Life Sciences
Issue number19
StatePublished - Oct 2008


  • C-type lectin
  • Cathelicidin
  • Defensin
  • Inflammatory bowel disease
  • Paneth cell

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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