@article{f670c1128c394155b4895fba4b7ae0cd,
title = "Msl3 promotes germline stem cell differentiation in female Drosophila",
abstract = "Gamete formation from germline stem cells (GSCs) is essential for sexual reproduction. However, the regulation of GSC differentiation is incompletely understood. Set2, which deposits H3K36me3 modifications, is required for GSC differentiation during Drosophila oogenesis. We discovered that the H3K36me3 reader Male-specific lethal 3 (Msl3) and histone acetyltransferase complex Ada2a-containing (ATAC) cooperate with Set2 to regulate GSC differentiation in female Drosophila. Msl3, acting independently of the rest of the male-specific lethal complex, promotes transcription of genes, including a germline-enriched ribosomal protein S19 paralog RpS19b. RpS19b upregulation is required for translation of RNA-binding Fox protein 1 (Rbfox1), a known meiotic cell cycle entry factor. Thus, Msl3 regulates GSC differentiation by modulating translation of a key factor that promotes transition to an oocyte fate.",
keywords = "Differentiation, Meiosis, Msl3, Rbfox1, RpS19, Set2",
author = "Alicia McCarthy and Kahini Sarkar and Martin, {Elliot T.} and Maitreyi Upadhyay and Seoyeon Jang and Williams, {Nathan D.} and Forni, {Paolo E.} and Michael Buszczak and Prashanth Rangan",
note = "Funding Information: This work is funded by the National Institutes of Health (2R01GM111770-06 and RO1GM135628 to P.M., R01GM125812 to M.B., and 1R15HD0964110, 1R01HD097331-01 and 1R01DC017149-01A1 to P.F.). Deposited in PMC for release after 12 months. Funding Information: We are grateful to Drs Marlow and Siekhaus for comments. We thank Drs Kuroda, Bach, Lehmann, Hawley, Bickel and Fuchs for reagents. We thank the Bloomington Drosophila Stock Center, the Vienna Drosophila Resource Center and the Transgenic RNAi Project (NIH/NIGMS R01-GM084947) for fly stocks. This work is funded by the National Institutes of Health (2R01GM111770-06 and RO1GM135628 to P.M., R01GM125812 to M.B., and 1R15HD0964110, 1R01HD097331-01 and 1R01DC017149-01A1 to P.F.). Deposited in PMC for release after 12 months. Publisher Copyright: {\textcopyright} 2022. Published by The Company of Biologists Ltd.",
year = "2022",
month = jan,
doi = "10.1242/DEV.199625",
language = "English (US)",
volume = "149",
journal = "Journal of Embryology and Experimental Morphology",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "1",
}