MRI thermometry based on PARACEST agents

Shanrong Zhang; Craig R. Malloy; A. Dean Sherry

doi:10.1021/ja053799t

MRI thermometry based on PARACEST agents

Shanrong Zhang, Craig R. Malloy, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

A novel magnetic resonance imaging (MRI) thermometry technique is demonstrated in vitro based upon the use of a PARACEST (PARAmagnetic Chemical Exchange Saturation Transfer) agent. This new method takes advantage of the high concentration of bulk water (the readout signal for imaging) and the hyperfine frequency shift properties of PARACEST agents. For two prototypes, Dy(1)³⁺ and Eu(2)^-, the chemical shifts (δ, in ppm) of the Ln³⁺-bound water molecules are linearly dependent on temperature (T, in °C) over the range of 20-50 °C (δ = 6.9 × T - 944.7 and δ = -0.4 × T + 64.6, respectively). This offers the exciting possibility of improving the temperature dependencies ∼690- and ∼40-fold over the most widely used water PRF thermometry (Proton Resonance Frequency: -0.01 ppm/°C).

Original language	English (US)
Pages (from-to)	17572-17573
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	50
DOIs	https://doi.org/10.1021/ja053799t
State	Published - Dec 21 2005

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "MRI thermometry based on PARACEST agents",

abstract = "A novel magnetic resonance imaging (MRI) thermometry technique is demonstrated in vitro based upon the use of a PARACEST (PARAmagnetic Chemical Exchange Saturation Transfer) agent. This new method takes advantage of the high concentration of bulk water (the readout signal for imaging) and the hyperfine frequency shift properties of PARACEST agents. For two prototypes, Dy(1)3+ and Eu(2)-, the chemical shifts (δ, in ppm) of the Ln3+-bound water molecules are linearly dependent on temperature (T, in °C) over the range of 20-50 °C (δ = 6.9 × T - 944.7 and δ = -0.4 × T + 64.6, respectively). This offers the exciting possibility of improving the temperature dependencies ∼690- and ∼40-fold over the most widely used water PRF thermometry (Proton Resonance Frequency: -0.01 ppm/°C).",

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T1 - MRI thermometry based on PARACEST agents

AU - Zhang, Shanrong

AU - Malloy, Craig R.

AU - Sherry, A. Dean

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N2 - A novel magnetic resonance imaging (MRI) thermometry technique is demonstrated in vitro based upon the use of a PARACEST (PARAmagnetic Chemical Exchange Saturation Transfer) agent. This new method takes advantage of the high concentration of bulk water (the readout signal for imaging) and the hyperfine frequency shift properties of PARACEST agents. For two prototypes, Dy(1)3+ and Eu(2)-, the chemical shifts (δ, in ppm) of the Ln3+-bound water molecules are linearly dependent on temperature (T, in °C) over the range of 20-50 °C (δ = 6.9 × T - 944.7 and δ = -0.4 × T + 64.6, respectively). This offers the exciting possibility of improving the temperature dependencies ∼690- and ∼40-fold over the most widely used water PRF thermometry (Proton Resonance Frequency: -0.01 ppm/°C).

AB - A novel magnetic resonance imaging (MRI) thermometry technique is demonstrated in vitro based upon the use of a PARACEST (PARAmagnetic Chemical Exchange Saturation Transfer) agent. This new method takes advantage of the high concentration of bulk water (the readout signal for imaging) and the hyperfine frequency shift properties of PARACEST agents. For two prototypes, Dy(1)3+ and Eu(2)-, the chemical shifts (δ, in ppm) of the Ln3+-bound water molecules are linearly dependent on temperature (T, in °C) over the range of 20-50 °C (δ = 6.9 × T - 944.7 and δ = -0.4 × T + 64.6, respectively). This offers the exciting possibility of improving the temperature dependencies ∼690- and ∼40-fold over the most widely used water PRF thermometry (Proton Resonance Frequency: -0.01 ppm/°C).

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MRI thermometry based on PARACEST agents

Abstract

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