MRI shows abnormal white matter maturation in classical holoprosencephaly

A. J. Barkovich, E. M. Simon, O. A. Glenn, N. J. Clegg, S. L. Kinsman, M. Delgado, J. S. Hahn

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


In an attempt to assess white matter maturation in holoprosencephaly (HPE), MRI scans of 47 patients with HPE were retrospectively reviewed. White matter maturation was delayed in 25/47 patients, including 24/29 patients with classic HPE who were ≤ 12 months old at the time of imaging. Of interest, all six patients with the middle interhemispheric (MIH) variant of HPE had normal myelination, regardless of age. This study provides further evidence that the classic and MIH variants of HPE have different underlying causes.

Original languageEnglish (US)
Pages (from-to)1968-1971
Number of pages4
Issue number12
StatePublished - Dec 24 2002

ASJC Scopus subject areas

  • Clinical Neurology


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