Abstract
In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC- in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC-, 200 μL of a 2-mM stock solution (corresponds to ∼0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.
Original language | English (US) |
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Pages (from-to) | 650-655 |
Number of pages | 6 |
Journal | Magnetic resonance in medicine |
Volume | 58 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2007 |
Keywords
- Contrast
- Exchange
- Low B WALTZ-16
- OPARACHEE
- PARACEST
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging