MR spectroscopy detects lipid peaks in cerebrotendinous xanthomatosis

E. K. Embiruçu, M. C.G. Otaduy, A. K. Taneja, C. C. Leite, Fernando Kok, L. T. Lucato

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation.

Original languageEnglish (US)
Pages (from-to)1347-1349
Number of pages3
JournalAmerican Journal of Neuroradiology
Issue number7
StatePublished - Aug 2010
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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