MR imaging of the corpus callosum in pediatric patients with neurofibromatosis type 1

E. C. Dubovsky, T. N. Booth, G. Vezina, C. A. Samango-Sprouse, K. M. Palmer, C. O. Brasseux

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46 Scopus citations


BACKGROUND AND PURPOSE: Many pediatric patients with neurofibromatosis type 1 (NF-1) have an apparent increased thickness of the corpus callosum (CC) on sagittal T1-weighted images compared with patients not affected by NF-1. In this study, we compared the surface area of the CC in children with NF-1 with that of healthy pediatric control subjects to determine if this was another common intracranial manifestation of NF-1. METHODS: Midsagittal T1-weighted MR images of 43 consecutive children with NF-1 and 43 age- and gender-matched healthy control subjects were reviewed retrospectively. The surface area of the CC and the midsagittal intracranial skull surface (MISS) area were measured five times each on all midsagittal images. A mean CC to mean midline intracranial surface area ratio (CC/MISS) was calculated for each. RESULTS: There is a statistically significant increase in the mean CC surface area in pediatric patients with NF-1 (680 mm2 ±98, range 509-974 mm2) compared with control subjects (573 mm2 ± 83, range 404-797 mm2). The mean MISS is significantly increased in patients with NF-1 (16568 mm2 ± 1161, range 14107-19394 mm2 vs 15402 mm2 ± 1133, range 12951-17905 mm2 for control subjects). CC/MISS was also significantly increased in the patients with NF-1 relative to the control subjects (.0410 ± .0043, range .0330-.0530 vs .0372 ± .0043, range .0270-.0470 for control subjects). CONCLUSION: A larger midsagittal surface area of the CC is another intracranial manifestation of NF-1 that can be demonstrated by sagittal MR imaging. The etiology is unclear, but could be related to abnormal neurofibromin and Ras protein activity. Potential clinical relevance is discussed herein.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalAmerican Journal of Neuroradiology
Issue number1
StatePublished - Feb 8 2001

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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