Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment

Hongdan Yang, Fengxia Zhang, Ching Jung Huang, Jun Liao, Ying Han, Piliang Hao, Youjun Chu, Xiaoai Lu, Wenshu Li, Hongtao Yu, Jungseog Kang

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Accurate partitioning of chromosomes during mitosis is essential for genetic stability and requires the assembly of the dynamic mitotic spindle and proper kinetochore-microtubule attachment. The spindle assembly checkpoint (SAC) monitors the incompleteness and errors in kinetochore-microtubule attachment and delays anaphase. The SAC kinase Mps1 regulates the recruitment of downstream effectors to unattached kinetochores. Mps1 also actively promotes chromosome alignment during metaphase, but the underlying mechanism is not completely understood. Here, we show that Mps1 regulates chromosome alignment through MCRS1, a spindle assembly factor that controls the dynamics of the minus end of kinetochore microtubules. Mps1 binds and phosphorylates MCRS1. This mechanism enables KIF2A localization to the minus end of spindle microtubules. Thus, our study reveals a novel role of Mps1 in regulating the dynamics of the minus end of microtubules and expands the functions of Mps1 in genome maintenance.

Original languageEnglish (US)
Pages (from-to)1060-1068
Number of pages9
JournalMolecular biology of the cell
Issue number9
StatePublished - 2019

ASJC Scopus subject areas

  • Medicine(all)


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