Mouse models of alzheimer's disease

Dwight C. German

doi:10.1007/978-1-84628-440-3_16

Mouse models of alzheimer's disease

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Transgenic mouse models have been created that mimic many of the neuropathologic and behavioral phenotypes of Alzheimer's disease (AD). Using mutations found in familial AD, the mouse models exhibit some of the cardinal features of the human disease. Wong et al. [1] and Higgins and Jacobsen [2] have written reviews of this topic. The current review extends a previous one [3] and will describe the similarities in the neuropathology of AD and the mouse models of the disease, specifically regarding neurodegeneration, and also describe treatments being developed using the mouse models.

Original language	English (US)
Title of host publication	Abeta Peptide and Alzheimer's Disease
Subtitle of host publication	Celebrating a Century of Research
Publisher	Springer London
Pages	259-273
Number of pages	15
ISBN (Print)	1852339616, 9781852339616
DOIs	https://doi.org/10.1007/978-1-84628-440-3_16
State	Published - Dec 1 2007

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-84628-440-3_16

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AB - Transgenic mouse models have been created that mimic many of the neuropathologic and behavioral phenotypes of Alzheimer's disease (AD). Using mutations found in familial AD, the mouse models exhibit some of the cardinal features of the human disease. Wong et al. [1] and Higgins and Jacobsen [2] have written reviews of this topic. The current review extends a previous one [3] and will describe the similarities in the neuropathology of AD and the mouse models of the disease, specifically regarding neurodegeneration, and also describe treatments being developed using the mouse models.

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Mouse models of alzheimer's disease

Abstract

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