Mouse models of alzheimer's disease

Research output: Chapter in Book/Report/Conference proceedingChapter


Transgenic mouse models have been created that mimic many of the neuropathologic and behavioral phenotypes of Alzheimer's disease (AD). Using mutations found in familial AD, the mouse models exhibit some of the cardinal features of the human disease. Wong et al. [1] and Higgins and Jacobsen [2] have written reviews of this topic. The current review extends a previous one [3] and will describe the similarities in the neuropathology of AD and the mouse models of the disease, specifically regarding neurodegeneration, and also describe treatments being developed using the mouse models.

Original languageEnglish (US)
Title of host publicationAbeta Peptide and Alzheimer's Disease
Subtitle of host publicationCelebrating a Century of Research
PublisherSpringer London
Number of pages15
ISBN (Print)1852339616, 9781852339616
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Medicine(all)


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