Motor neuron disease lymphoproliferative disease, and bone marrow biopsy

Elan D. Louis, Ann E. Hanley, Thomas H. Brannagan, William Sherman, Peregrine Murphy, Dale J. Lange, Werner Trojaborg, David S. Younger, Robert E. Lovelace, Norman Latov, Lewis P. Rowland

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Some have suggested that nonfamilial motor neuron disease (MND) may be autoimmune, and the neurological disorder may benefit from immunotherapy. There have been reports of over 30 cases of lymphoproliferative disease (lymphoma, multiple myeloma, Waldenstrom's macroglobulinemia) with MND, and these patients might be offered immunosuppressive therapy. Bone marrow examination might increase the sensitivity of the diagnostic workup for lymphoma and other lymphoproliferative disorders. We examined the bone marrow in our first evaluation of 161 patients with MND seen at Columbia- Presbyterian Medical Center during 1991-1994. Four of 161 patients (2.5%) had lymphoproliferative disease in the marrow; only 1 of these had a monoclonal paraprotein. Routine bone marrow examination of patients with MND increases the diagnostic yield of lymphoproliferative diseases. The frequency of these bone marrow abnormalities in comparison with a group of age-matched control subjects should be studied further.

Original languageEnglish (US)
Pages (from-to)1334-1337
Number of pages4
JournalMuscle and Nerve
Issue number10
StatePublished - 1996
Externally publishedYes


  • bone marrow biopsy
  • lymphoma
  • lymphoproliferative disease
  • motor neuron disease
  • multiple myeloma

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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