TY - JOUR
T1 - Mortality among infants with evolving bronchopulmonary dysplasia increases with major surgery and with pulmonary hypertension
AU - Devries, L. B.
AU - Heyne, R. J.
AU - Ramaciotti, C.
AU - Brown, L. S.
AU - Jaleel, M. A.
AU - Kapadia, V. S.
AU - Burchfield, P. J.
AU - Brion, L. P.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Objective:To assess whether mortality in patients with evolving bronchopulmonary dysplasia (BPD, defined as >8 days of oxygen exposure with lung disease) is independently associated with pulmonary arterial hypertension (PAH) and surgery.Study Design:Single institution retrospective birth cohort of preterm infants with gestational age (GA) 23 0/7 to 36 6/7 weeks, and evolving BPD delivered between 2001 and 2014. Surgery was classified as minor or major using published criteria. Mortality was analyzed by stepwise logistic regression analysis.Results:Among 577 patients with evolving BPD, 33 (6%) died prior to discharge. Mortality decreased with GA (adjusted odds ratio (aOR): 0.69; 95% confidence interval (CI): 0.55, 0.87), birth weight Z-score (aOR: 0.69, 95% CI: 0.47, 0.996) and increased with PAH (aOR: 30, 95% CI: 2.1, 415), major surgery (aOR; 2.8, 95% CI: 1.3, 6.3), and PAH and surgery (aOR: 10.3, 95% CI: 2.5, 42.1).Conclusion:Among preterm patients with evolving BPD, PAH and surgery are independently associated with mortality.
AB - Objective:To assess whether mortality in patients with evolving bronchopulmonary dysplasia (BPD, defined as >8 days of oxygen exposure with lung disease) is independently associated with pulmonary arterial hypertension (PAH) and surgery.Study Design:Single institution retrospective birth cohort of preterm infants with gestational age (GA) 23 0/7 to 36 6/7 weeks, and evolving BPD delivered between 2001 and 2014. Surgery was classified as minor or major using published criteria. Mortality was analyzed by stepwise logistic regression analysis.Results:Among 577 patients with evolving BPD, 33 (6%) died prior to discharge. Mortality decreased with GA (adjusted odds ratio (aOR): 0.69; 95% confidence interval (CI): 0.55, 0.87), birth weight Z-score (aOR: 0.69, 95% CI: 0.47, 0.996) and increased with PAH (aOR: 30, 95% CI: 2.1, 415), major surgery (aOR; 2.8, 95% CI: 1.3, 6.3), and PAH and surgery (aOR: 10.3, 95% CI: 2.5, 42.1).Conclusion:Among preterm patients with evolving BPD, PAH and surgery are independently associated with mortality.
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U2 - 10.1038/jp.2017.89
DO - 10.1038/jp.2017.89
M3 - Article
C2 - 28617427
AN - SCOPUS:85032709536
SN - 0743-8346
VL - 37
SP - 1043
EP - 1046
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 9
ER -