@article{2c053a29753e4080801c649377409f49,
title = "Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data",
abstract = "Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a new model of SCLC subtypes defined by differential expression of four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. Defining the unique therapeutic vulnerabilities of these subtypes of SCLC should help to focus and accelerate therapeutic research, leading to rationally targeted approaches that may ultimately improve clinical outcomes for patients with this disease.",
author = "Rudin, {Charles M.} and Poirier, {John T.} and Byers, {Lauren Averett} and Caroline Dive and Afshin Dowlati and Julie George and Heymach, {John V.} and Johnson, {Jane E.} and Lehman, {Jonathan M.} and David MacPherson and Massion, {Pierre P.} and Minna, {John D.} and Oliver, {Trudy G.} and Vito Quaranta and Julien Sage and Thomas, {Roman K.} and Vakoc, {Christopher R.} and Gazdar, {Adi F.}",
note = "Funding Information: The authors thank N. Rekhtman for insightful comment regarding pathological criteria for small cell lung cancer diagnosis. This work was supported by grants from the US National Institutes of Health, including U24CA213274 (C.M.R., J.T.P., A.D., J.D.M. and A.F.G.), R01CA197936 (C.M.R., J.T.P. and C.D.), R01CA207295 (L.A.B.), U01CA213273 (L.A.B., J.V.H. and J.S.), P50CA70907 and U01CA213338 (J.E.J., J.D.M. and A.F.G.), U54CA217450 (J.M.L. and V.Q.), UG1CA233259 (J.M.L.) and R21CA216504 (T.G.O.); by Veterans Affairs Merit Review I01CX001425 (P.P.M.); by a LUNGevity Foundation Career Development Award (J.M.L.); and by Cancer Research UK A27412, A25254 and A20465 (C.D.). Publisher Copyright: {\textcopyright} 2019, The Publisher.",
year = "2019",
month = may,
day = "1",
doi = "10.1038/s41568-019-0133-9",
language = "English (US)",
volume = "19",
pages = "289--297",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "5",
}