Molecular signatures of pancreatic cancer

Seung Mo Hong, Jason Y. Park, Ralph H. Hruban, Michael Goggins

Research output: Contribution to journalArticlepeer-review

138 Scopus citations


The introduction of genome- and epigenomewide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. Each of these precursor lesions is associated with specific molecular alterations. Objective.-To understand the molecular characteristics of pancreatic ductal adenocarcinoma and its precursor lesions. Data Sources.-PubMed (US National Library of Medicine). Conclusions.-In this review, we briefly summarize recent research findings on the genetics and epigenetics of pancreatic cancer. In addition, we characterize these molecular alterations in the context of the histologic subtypes of pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)716-727
Number of pages12
JournalArchives of Pathology and Laboratory Medicine
Issue number6
StatePublished - Jun 2011

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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