@inproceedings{f9082260a1b749e6b94f62c5c87a764f,
title = "Molecular photoacoustic imaging using gold nanoparticles as a contrast agent",
abstract = "Gold nanoparticles have received much attention due to their potential diagnostic and therapeutic applications. Gold nanoparticles are attractive in many biomedical applications because of their biocompatibility, easily modifiable surfaces for targeting, lack of heavy metal toxicity, wide range of sizes (35-100 nm), tunable plasmonic resonance peak, encapsulated site-specific drug delivery, and strong optical absorption in the near-infrared regime. Specifically, due to their strong optical absorption, gold nanoparticles have been used as a contrast agent for molecular photoacoustic (PA) imaging of tumor. The plasmonic resonance peak of the gold nanocages (AuNCs) was tuned to the near-infrared region, and the ratio of the absorption cross-section to the extinction cross-section was approximately ~70%, as measured by PA sensing. We used PEGylated gold nanocages (PEG-AuNCs) as a passive targeting contrast agent on melanomas. After 6-h intravenous injection of PEG-AuNCs, PA amplitude was increased by ∼14 %. These results strongly suggest PA imaging paired with AuNCs is a promising diagnostic tool for early cancer detection.",
keywords = "B16 melanoma, Gold nanoparticles, Molecular imaging, Photoacoustic tomography",
author = "Chulhong Kim and Cho, {Eun Chul} and Jingyi Chen and Song, {Kwang Hyun} and Leslie Au and Favazza, {Christopher P.} and Qiang Zhang and Cobley, {Claire M.} and Younan Xia and Wang, {Lihong V.}",
year = "2010",
doi = "10.1117/12.843549",
language = "English (US)",
isbn = "9780819479600",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2010 ; Conference date: 24-01-2010 Through 26-01-2010",
}