@article{55981bbfa1af44d793b194503cad6186,
title = "Molecular Mechanisms and Therapeutics for Spinocerebellar Ataxia Type 2",
abstract = "The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar ataxia type 2 (SCA2) (a progressive hereditary disease caused by an expansion of polyglutamine in the ataxin-2 protein) is not available yet. At present, only symptomatic treatment and methods of palliative care are prescribed to the patients. Many attempts were made to study the physiological, molecular, and biochemical changes in SCA2 patients and in a variety of the model systems to find new therapeutic targets for SCA2 treatment. A better understanding of the uncovered molecular mechanisms of the disease allowed the scientific community to develop strategies of potential therapy and helped to create some promising therapeutic approaches for SCA2 treatment. Recent progress in this field will be discussed in this review article.",
keywords = "Spinocerebellar ataxia type 2, aggregation, calcium signaling, cerebellum, polyglutamine disorders",
author = "Egorova, {Polina A.} and Bezprozvanny, {Ilya B.}",
note = "Funding Information: Ilya B. Bezprozvanny is a holder of the Carl J. and Hortense M. Thomsen Chair in Alzheimer{\textquoteright}s Disease Research. This work was supported by the National Institutes of Health Grant R01NS056224 (Ilya B. Bezprozvanny), Russian State Grant 17.991.2017/4.6 (Ilya B. Bezprozvanny), Russian Science Foundation Grant 18-75-00025 (Polina A. Egorova), Presidential Grant МК-1299.2019.4 (Polina A. Egorova), and Russian Science Foundation Grant 19-15-00184 (Ilya B. Bezprozvanny). The financial support was divided in the following way: research work related to Figure 1 was supported by the Russian State Grant 17.991.2017/4.6, research work related to Figure 2 was supported by the Presidential Grant МК-1299.2019.4, research work related to Figure 3 was supported by the Russian Science Foundation Grant 18-75-00025, and research work related to Figure 4 was supported by the Russian Science Foundation Grant 19-15-00184. Publisher Copyright: {\textcopyright} 2019, The American Society for Experimental NeuroTherapeutics, Inc.",
year = "2019",
month = oct,
day = "1",
doi = "10.1007/s13311-019-00777-6",
language = "English (US)",
volume = "16",
pages = "1050--1073",
journal = "Neurotherapeutics",
issn = "1933-7213",
publisher = "Springer New York",
number = "4",
}