Molecular control of myogenesis: antagonism between growth and differentiation

Eric N. Olson, Thomas J. Brennan, Tushar Chakraborty, Tse Cheng Cheng, Peter Cserjesi, Diane Edmondson, Guy James, Li Li

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Insight into the molecular mechanisms that control establishment of the skeletal muscle phenotype has recently been obtained through cloning of a family of muscle-specific regulatory factors that can activate myogenesis when transfected into non-muscle cells. This family of factors, which includes MyoD, myogenin, myf-5, and MRF4, can bind DNA and transactivate muscle-specific genes in collaboration with ubiquitous cellular factors. Growth factors play an antagonistic role in myogenesis by suppressing the actions of the myogenic regulatory factor family. This review will focus on the regulation and mechanism of action of this family of myogenic regulatory factors and on the central role of peptide growth factors in modulating their expression and biological activities.

Original languageEnglish (US)
Pages (from-to)7-13
Number of pages7
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - May 1991


  • growth factors
  • helix-loop-helix proteins
  • myogenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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