Molecular cloning and characterization of alpha-subunit isoforms of the Na,K-ATPase.

R. W. Mercer, J. W. Schneider, E. J. Benz

Research output: Contribution to journalArticlepeer-review


The identification of the different alpha-subunit isoforms of the Na,K-ATPase has added an unexpected complexity to the understanding of the function and regulation of this important transport protein. Our results indicate that the alpha, alpha(+) and alpha III isoform mRNAs have distinct, but partially overlapping, distributions in brain and peripheral tissues. Also, characterization of mRNA distribution in fetal tissues suggests that the Na,K-ATPase alpha-subunit isoforms are regulated during development and differentiation. The developmental regulation and strikingly different tissue specificities of the three alpha-subunit isoforms suggests that the different Na,K-ATPase alpha-subunits may be adapted to perform different roles in maintaining sodium and potassium homeostasis.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalProgress in clinical and biological research
Volume268 B
StatePublished - 1988

ASJC Scopus subject areas

  • Medicine(all)


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