TY - JOUR
T1 - Molecular and genetic insights into T cell antigen receptor signal transduction
AU - Weiss, A.
AU - Iwashima, M.
AU - Irving, B.
AU - Van Oers, N. S C
AU - Kadlecek, T. A.
AU - Straus, D.
AU - Chan, A.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The T cell response to antigen is initiated by the TCR through its ability to regulate the phosphorylation of tyrosine residues of critical intracellular molecules. The TCR uses a modular system in which sequence motifs, ARAMs, within the ζ and CD3 chains to communicate with intracellular PTKs. These PTK interact with the TCR in a sequential and coordinated manner. This rather complex modular system may have evolved to insure that all requirement of the signalling mechanism are met before a response is initiated. Mistakes could result in autoimmunity. It is likely that the general features of this system will reflect the events involved in B cell antigen receptor and IgE Fc receptor signal transduction since ARAMs as well as Src and Syk/ZAP-70 family members are used in these systems as well.
AB - The T cell response to antigen is initiated by the TCR through its ability to regulate the phosphorylation of tyrosine residues of critical intracellular molecules. The TCR uses a modular system in which sequence motifs, ARAMs, within the ζ and CD3 chains to communicate with intracellular PTKs. These PTK interact with the TCR in a sequential and coordinated manner. This rather complex modular system may have evolved to insure that all requirement of the signalling mechanism are met before a response is initiated. Mistakes could result in autoimmunity. It is likely that the general features of this system will reflect the events involved in B cell antigen receptor and IgE Fc receptor signal transduction since ARAMs as well as Src and Syk/ZAP-70 family members are used in these systems as well.
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U2 - 10.1007/978-1-4899-0987-9_6
DO - 10.1007/978-1-4899-0987-9_6
M3 - Review article
C2 - 7887313
AN - SCOPUS:0027959722
SN - 0065-2598
VL - 365
SP - 53
EP - 62
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -