Molecular and Genetic Bases for the Circadian System

C. H. Ko, J. S. Takahashi

Research output: Chapter in Book/Report/Conference proceedingChapter


Circadian rhythms represent an evolutionarily conserved adaptation to the environment that can be traced back to the earliest life forms. In animals, circadian behavior can be analyzed as an integrated system beginning with genes and leading ultimately to behavioral outputs. In the last decade, the molecular mechanism of circadian clocks has been uncovered by the use of phenotype-driven (forward) genetic analysis in a number of model systems. Circadian oscillations are generated by a set of genes forming a transcriptional autoregulatory feedback loop. Here, the molecular basis of circadian rhythms and the influence of circadian mutations on sleep are reviewed.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Sleep
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780123786111
ISBN (Print)9780123786104
StatePublished - Jan 1 2013


  • Biological clock
  • Bmal1
  • Casein kinase 1
  • Circadian rhythms
  • Clock
  • Cryptochrome
  • Npas2
  • Period
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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