Abstract
The rational design of materials with cell-selective membrane activity is an effective strategy for the development of targeted molecular imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme-mediated molecular transformation followed by supramolecular assembly to form nanofibers in which cationic clusters are presented on a rigid β-sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self-assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramolecular nanomaterials with emerging membrane activity for a range of disease targeted molecular imaging and therapy applications.
Original language | English (US) |
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Pages (from-to) | 3164-3168 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 22 |
Issue number | 22 |
DOIs | |
State | Published - Nov 16 2021 |
Keywords
- cell selectivity
- drug delivery
- membrane activity
- molecular imaging
- self-assembly
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry