Modifying ligand specificity of gene regulatory proteins

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Nuclear receptors contain a conserved hydrophobic ligand binding pocket that is particularly amenable to structure-based protein engineering. Thus, site-directed mutagenesis of the ligand binding pocket has resulted in the creation of nuclear receptors with novel ligand specificities. Such proteins are now being used to control gene expression in vivo in a ligand-dependent manner.

Original languageEnglish (US)
Pages (from-to)60-64
Number of pages5
JournalCurrent Opinion in Chemical Biology
Issue number1
StatePublished - Feb 1 2000

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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