Abstract
Nuclear receptors contain a conserved hydrophobic ligand binding pocket that is particularly amenable to structure-based protein engineering. Thus, site-directed mutagenesis of the ligand binding pocket has resulted in the creation of nuclear receptors with novel ligand specificities. Such proteins are now being used to control gene expression in vivo in a ligand-dependent manner.
Original language | English (US) |
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Pages (from-to) | 60-64 |
Number of pages | 5 |
Journal | Current Opinion in Chemical Biology |
Volume | 4 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2000 |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry