Abstract
The effect of orally administered type 1 interferons on the severity of acute experimental autoimmune encephalomyelitis (EAE), a T cell-mediated autoimmune disease, was examined by inoculation of Lewis rats with guinea pig myelin basic protein (GPMBP) and complete Freund's adjuvant. Rats were fed either rat species-specific or human recombinant type 1 interferon (IFN) or mock IFN daily for 7 days preceding immunization and for 21 days thereafter. There was a significant decrease in the clinical score and inflammatory foci in animals fed 5000 units IFN compared with mock-treated animals. There was a significant decrease in clinical score and number of inflammatory foci in spinal cord in animals fed orally 5000 units human recombinant IFN-α PO compared with SC 5000 units recombinant human IFN-α. Oral administration of type 1 interferon, as opposed to subcutaneous administration, inhibited the secretion of IFN-γ from ConA-activated draining popliteal lymph node cells compared with mock-fed animals. These experiments demonstrate that acute EAE is more effectively inhibited by equivalent amounts of orally in contrast to parenterally administered IFN-α. These results suggest that type 1 IFNs are active by the oral route and have significant clinical and histologic effects in acute autoimmune disease.
Original language | English (US) |
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Pages (from-to) | 115-122 |
Number of pages | 8 |
Journal | Journal of Interferon and Cytokine Research |
Volume | 15 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1995 |
ASJC Scopus subject areas
- Immunology
- Cell Biology
- Virology