Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research

Zijian Deng; Xiangkun Xu; Iulian Iordachita; Hamid Dehghani; Bin Zhang; John W. Wong; Ken Kang Hsin Wang

doi:10.1364/BOE.460737

Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research

Zijian Deng, Xiangkun Xu, Iulian Iordachita, Hamid Dehghani, Bin Zhang, John W. Wong, Ken Kang Hsin Wang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing in vivo soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and in vivo validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.

Original language	English (US)
Pages (from-to)	4970-4989
Number of pages	20
Journal	Biomedical Optics Express
Volume	13
Issue number	9
DOIs	https://doi.org/10.1364/BOE.460737
State	Published - Sep 1 2022

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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title = "Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research",

abstract = "Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing in vivo soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and in vivo validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.",

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AU - Deng, Zijian

AU - Xu, Xiangkun

AU - Iordachita, Iulian

AU - Dehghani, Hamid

AU - Zhang, Bin

AU - Wong, John W.

AU - Wang, Ken Kang Hsin

PY - 2022/9/1

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AB - Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing in vivo soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and in vivo validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.

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Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research

Abstract

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