Mitochondria in Acute Kidney Injury

Kenneth M. Ralto, Samir M. Parikh

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and health care expenditure. In the United States alone, it is estimated that more than $10 billion is spent on AKI every year. Currently, there are no available therapies to treat established AKI. The mitochondrion is positioned to be a critical player in AKI with its dual role as the primary source of energy for each cell and as a key regulator of cell death. This review aims to cover the current state of research on the role of mitochondria in AKI, while also proposing potential therapeutic targets and future therapies.

Original languageEnglish (US)
Pages (from-to)8-16
Number of pages9
JournalSeminars in nephrology
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • Acute kidney injury
  • Metabolism
  • Mitochondria
  • Reactive oxygen species

ASJC Scopus subject areas

  • Nephrology


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