Mitochondria in Acute Kidney Injury

Kenneth M. Ralto; Samir M. Parikh

doi:10.1016/j.semnephrol.2016.01.005

Mitochondria in Acute Kidney Injury

Kenneth M. Ralto, Samir M. Parikh

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Abstract

Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and health care expenditure. In the United States alone, it is estimated that more than $10 billion is spent on AKI every year. Currently, there are no available therapies to treat established AKI. The mitochondrion is positioned to be a critical player in AKI with its dual role as the primary source of energy for each cell and as a key regulator of cell death. This review aims to cover the current state of research on the role of mitochondria in AKI, while also proposing potential therapeutic targets and future therapies.

Original language	English (US)
Pages (from-to)	8-16
Number of pages	9
Journal	Seminars in nephrology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.semnephrol.2016.01.005
State	Published - Jan 1 2016
Externally published	Yes

Keywords

Acute kidney injury
Metabolism
Mitochondria
Reactive oxygen species

ASJC Scopus subject areas

Nephrology

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10.1016/j.semnephrol.2016.01.005

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abstract = "Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and health care expenditure. In the United States alone, it is estimated that more than $10 billion is spent on AKI every year. Currently, there are no available therapies to treat established AKI. The mitochondrion is positioned to be a critical player in AKI with its dual role as the primary source of energy for each cell and as a key regulator of cell death. This review aims to cover the current state of research on the role of mitochondria in AKI, while also proposing potential therapeutic targets and future therapies.",

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AU - Ralto, Kenneth M.

AU - Parikh, Samir M.

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Y1 - 2016/1/1

N2 - Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and health care expenditure. In the United States alone, it is estimated that more than $10 billion is spent on AKI every year. Currently, there are no available therapies to treat established AKI. The mitochondrion is positioned to be a critical player in AKI with its dual role as the primary source of energy for each cell and as a key regulator of cell death. This review aims to cover the current state of research on the role of mitochondria in AKI, while also proposing potential therapeutic targets and future therapies.

AB - Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and health care expenditure. In the United States alone, it is estimated that more than $10 billion is spent on AKI every year. Currently, there are no available therapies to treat established AKI. The mitochondrion is positioned to be a critical player in AKI with its dual role as the primary source of energy for each cell and as a key regulator of cell death. This review aims to cover the current state of research on the role of mitochondria in AKI, while also proposing potential therapeutic targets and future therapies.

KW - Acute kidney injury

KW - Metabolism

KW - Mitochondria

KW - Reactive oxygen species

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JO - Seminars in nephrology

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Mitochondria in Acute Kidney Injury

Abstract

Keywords

ASJC Scopus subject areas

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