Milk lipid regulation at the maternal-offspring interface

Dengbao Yang, Hoang Dinh Huynh, Yihong Wan

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Milk lipids provide a large proportion of energy, nutrients, essential fatty acids, and signaling molecules for the newborns, the synthesis of which is a tightly controlled process. Dysregulated milk lipid production and composition may be detrimental to the growth, development, health and survival of the newborns. Many genetically modified animal models have contributed to our understanding of milk lipid regulation in the lactating mammary gland. In this review, we discuss recent advances in our knowledge of the mechanisms that control milk lipid biosynthesis and secretion during lactation, and how maternal genetic and dietary defects impact milk lipid composition and consequently offspring traits.

Original languageEnglish (US)
Pages (from-to)141-148
Number of pages8
JournalSeminars in Cell and Developmental Biology
StatePublished - Sep 2018


  • Genetic defect
  • High fat diet
  • Inflammatory milk
  • Lactating mammary gland
  • Milk lipid

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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