Few studies have examined an association between mild traumatic brain injury (mTBI) and Alzheimer's disease (AD). For this reason, we compared an AD dementia group with an mTBI history (n = 10) to a matched AD control group (n = 20) on measures of cognitive function, cerebral glucose metabolism, and markers of amyloid and tau deposition. Only a trend and medium-to-large effect size for higher phosphorylated and total tau was identified for the mTBI group. A history of mTBI may be associated with greater tau in AD, indicating a potential pathway for increasing risk for AD, though further evaluation with larger samples is needed.

Original languageEnglish (US)
Pages (from-to)1491-1496
Number of pages6
JournalJournal of Alzheimer's Disease
Issue number4
StatePublished - 2022


  • Biomarkers
  • concussion
  • dementia
  • neurodegeneration
  • risk factor
  • tau formation
  • traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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