MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets

Eva Van Rooij; Eric N. Olson

doi:10.1172/JCI33099

MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets

Eva Van Rooij, Eric N. Olson

Research output: Contribution to journal › Review article › peer-review

466 Scopus citations

Abstract

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

Original language	English (US)
Pages (from-to)	2369-2376
Number of pages	8
Journal	Journal of Clinical Investigation
Volume	117
Issue number	9
DOIs	https://doi.org/10.1172/JCI33099
State	Published - Sep 4 2007

ASJC Scopus subject areas

General Medicine

Access to Document

10.1172/JCI33099

Cite this

@article{20a8610fc9c744bbabfe923c96c4bccc,

title = "MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets",

abstract = "MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.",

author = "{Van Rooij}, Eva and Olson, {Eric N.}",

year = "2007",

month = sep,

day = "4",

doi = "10.1172/JCI33099",

language = "English (US)",

volume = "117",

pages = "2369--2376",

journal = "Journal of Clinical Investigation",

issn = "0021-9738",

publisher = "The American Society for Clinical Investigation",

number = "9",

}

TY - JOUR

T1 - MicroRNAs

T2 - Powerful new regulators of heart disease and provocative therapeutic targets

AU - Van Rooij, Eva

AU - Olson, Eric N.

PY - 2007/9/4

Y1 - 2007/9/4

N2 - MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

AB - MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

UR - http://www.scopus.com/inward/record.url?scp=34848838292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848838292&partnerID=8YFLogxK

U2 - 10.1172/JCI33099

DO - 10.1172/JCI33099

M3 - Review article

C2 - 17786230

AN - SCOPUS:34848838292

SN - 0021-9738

VL - 117

SP - 2369

EP - 2376

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 9

ER -

MicroRNAs: Powerful new regulators of heart disease and provocative therapeutic targets

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this