microRNAs in Oligodendrocyte Myelination and Repair in the Central Nervous System

Xianghui Zhao; Haibo Wang; Qing Richard Lu

doi:10.1016/B978-0-12-804402-5.00011-X

microRNAs in Oligodendrocyte Myelination and Repair in the Central Nervous System

Xianghui Zhao, Haibo Wang, Qing Richard Lu

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The crucial role of microRNAs (miRNAs) in glial cell development, especially in development of myelinating cells in the central nervous system, has begun to be elucidated in recent years through functional analysis of the miRNA processing enzyme Dicer1 and identification of miRNAs expressed in myelinating cells. In this chapter, we discuss how miRNAs regulate oligodendrocyte development and myelination. We highlight the recent advances in our understanding of how miRNAs control oligodendrogenesis, proliferation, differentiation, myelinogenesis, myelin maintenance, and repair. We also discuss how miRNAs influence brain cancer formation and progression of debilitating neurological diseases. Finally, we summarize perspectives in utilizing miRNAs as diagnostic markers and therapeutics in demyelinating diseases.

Original language	English (US)
Title of host publication	Essentials of Noncoding RNA in Neuroscience
Subtitle of host publication	Ontogenetics, Plasticity of the Vertebrate Brain
Publisher	Elsevier Inc.
Pages	197-210
Number of pages	14
ISBN (Electronic)	9780128498996
ISBN (Print)	9780128044025
DOIs	https://doi.org/10.1016/B978-0-12-804402-5.00011-X
State	Published - Jan 1 2017

Keywords

Brain cancers
Demyelinating diseases
Dicer
MicroRNA
MiR-219
Multiple sclerosis
Myelination
Oligodendrocytes
Schwann cells

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/B978-0-12-804402-5.00011-X

Cite this

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abstract = "The crucial role of microRNAs (miRNAs) in glial cell development, especially in development of myelinating cells in the central nervous system, has begun to be elucidated in recent years through functional analysis of the miRNA processing enzyme Dicer1 and identification of miRNAs expressed in myelinating cells. In this chapter, we discuss how miRNAs regulate oligodendrocyte development and myelination. We highlight the recent advances in our understanding of how miRNAs control oligodendrogenesis, proliferation, differentiation, myelinogenesis, myelin maintenance, and repair. We also discuss how miRNAs influence brain cancer formation and progression of debilitating neurological diseases. Finally, we summarize perspectives in utilizing miRNAs as diagnostic markers and therapeutics in demyelinating diseases.",

keywords = "Brain cancers, Demyelinating diseases, Dicer, MicroRNA, MiR-219, Multiple sclerosis, Myelination, Oligodendrocytes, Schwann cells",

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AU - Zhao, Xianghui

AU - Wang, Haibo

AU - Lu, Qing Richard

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N2 - The crucial role of microRNAs (miRNAs) in glial cell development, especially in development of myelinating cells in the central nervous system, has begun to be elucidated in recent years through functional analysis of the miRNA processing enzyme Dicer1 and identification of miRNAs expressed in myelinating cells. In this chapter, we discuss how miRNAs regulate oligodendrocyte development and myelination. We highlight the recent advances in our understanding of how miRNAs control oligodendrogenesis, proliferation, differentiation, myelinogenesis, myelin maintenance, and repair. We also discuss how miRNAs influence brain cancer formation and progression of debilitating neurological diseases. Finally, we summarize perspectives in utilizing miRNAs as diagnostic markers and therapeutics in demyelinating diseases.

AB - The crucial role of microRNAs (miRNAs) in glial cell development, especially in development of myelinating cells in the central nervous system, has begun to be elucidated in recent years through functional analysis of the miRNA processing enzyme Dicer1 and identification of miRNAs expressed in myelinating cells. In this chapter, we discuss how miRNAs regulate oligodendrocyte development and myelination. We highlight the recent advances in our understanding of how miRNAs control oligodendrogenesis, proliferation, differentiation, myelinogenesis, myelin maintenance, and repair. We also discuss how miRNAs influence brain cancer formation and progression of debilitating neurological diseases. Finally, we summarize perspectives in utilizing miRNAs as diagnostic markers and therapeutics in demyelinating diseases.

KW - Brain cancers

KW - Demyelinating diseases

KW - Dicer

KW - MicroRNA

KW - MiR-219

KW - Multiple sclerosis

KW - Myelination

KW - Oligodendrocytes

KW - Schwann cells

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BT - Essentials of Noncoding RNA in Neuroscience

PB - Elsevier Inc.

ER -

microRNAs in Oligodendrocyte Myelination and Repair in the Central Nervous System

Abstract

Keywords

ASJC Scopus subject areas

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