MicroRNAs in cell proliferation, cell death, and tumorigenesis

H. W. Hwang; J. T. Mendell

doi:10.1038/sj.bjc.6603023

MicroRNAs in cell proliferation, cell death, and tumorigenesis

H. W. Hwang, J. T. Mendell

Research output: Contribution to journal › Short survey › peer-review

1028 Scopus citations

Abstract

MicroRNAs (miRNAs) are a recently discovered class of ∼ 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.

Original language	English (US)
Pages (from-to)	776-780
Number of pages	5
Journal	British journal of cancer
Volume	94
Issue number	6
DOIs	https://doi.org/10.1038/sj.bjc.6603023
State	Published - Mar 27 2006

Keywords

Apoptosis
Cellular proliferation
MicroRNAs
Oncogene
Tumour suppressor

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/sj.bjc.6603023

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AB - MicroRNAs (miRNAs) are a recently discovered class of ∼ 18-24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.

KW - Apoptosis

KW - Cellular proliferation

KW - MicroRNAs

KW - Oncogene

KW - Tumour suppressor

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MicroRNAs in cell proliferation, cell death, and tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

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