Microcytosis associated with sickle cell anemia

B. E. Glader, R. D. Propper, G. R. Buchanan

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10 Scopus citations


Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.

Original languageEnglish (US)
Pages (from-to)63-64
Number of pages2
JournalAmerican journal of clinical pathology
Issue number1
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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