Microcytosis associated with sickle cell anemia

B. E. Glader; R. D. Propper; G. R. Buchanan

doi:10.1093/ajcp/72.1.63

Microcytosis associated with sickle cell anemia

B. E. Glader, R. D. Propper, G. R. Buchanan

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Abstract

Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.

Original language	English (US)
Pages (from-to)	63-64
Number of pages	2
Journal	American journal of clinical pathology
Volume	72
Issue number	1
DOIs	https://doi.org/10.1093/ajcp/72.1.63
State	Published - Jan 1 1979

ASJC Scopus subject areas

Pathology and Forensic Medicine

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abstract = "Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.",

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T1 - Microcytosis associated with sickle cell anemia

AU - Glader, B. E.

AU - Propper, R. D.

AU - Buchanan, G. R.

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N2 - Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.

AB - Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 ± 2.4 μμg and mean corpuscular volume (MCV) was 88.1 ± 6.8 cu μm. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 ± 1.8 μμg) and larger MCV (97 ± 5.3 cu μm). These data indicate that Hb SS disease is associated with 'relative microcytosis', presumably a consequence of reduced hemoglobin production.

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Microcytosis associated with sickle cell anemia

Abstract

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