Microbubble compositions, properties and biomedical applications

S. R. Sirsi, M. A. Borden

Research output: Contribution to journalReview articlepeer-review

433 Scopus citations


Over the last decade, there has been a significant progress towards the development of microbubbles as theranostics for a wide variety of biomedical applications. The unique ability of microbubbles to respond to ultrasound makes them useful agents for contrast ultrasound imaging, molecular imaging, and targeted drug and gene delivery. The general composition of a microbubble is a gas core stabilised by a shell comprised of proteins, lipids or polymers. Each type of microbubble has its own unique advantages and can be tailored for specialised functions. In this review, different microbubbles compositions and physiochemical properties are discussed in the context of current progress towards developing novel constructs for biomedical applications, with specific emphasis on molecular imaging and targeted drug/gene delivery.

Original languageEnglish (US)
Pages (from-to)3-17
Number of pages15
JournalBubble Science, Engineering and Technology
Issue number1-2
StatePublished - 2009


  • Colloidal bubbles
  • Gas filled microparticles
  • Hollow microspheres
  • Spherical foams
  • Targeted drug and gene delivery
  • Ultrasound molecular imaging

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Science(all)


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