TY - JOUR
T1 - Microbiota and maintenance of skin barrier function
AU - Harris-Tryon, Tamia A.
AU - Grice, Elizabeth A.
N1 - Publisher Copyright:
© 2022 American Association for the Advancement of Science. All rights reserved.
PY - 2022/5/27
Y1 - 2022/5/27
N2 - Human skin forms a protective barrier against the external environment and is our first line of defense against toxic, solar, and pathogenic insults. Our skin also defines our outward appearance, protects our internal tissues and organs, acts as a sensory interface, and prevents dehydration. Crucial to the skin's barrier function is the colonizing microbiota, which provides protection against pathogens, tunes immune responses, and fortifies the epithelium. Here we highlight recent advances in our understanding of how the microbiota mediates multiple facets of skin barrier function. We discuss recent insights into pathological host-microbiota interactions and implications for disorders of the skin and distant organs. Finally, we examine how microbiota-based mechanisms can be targeted to prevent or manage skin disorders and impaired wound healing.
AB - Human skin forms a protective barrier against the external environment and is our first line of defense against toxic, solar, and pathogenic insults. Our skin also defines our outward appearance, protects our internal tissues and organs, acts as a sensory interface, and prevents dehydration. Crucial to the skin's barrier function is the colonizing microbiota, which provides protection against pathogens, tunes immune responses, and fortifies the epithelium. Here we highlight recent advances in our understanding of how the microbiota mediates multiple facets of skin barrier function. We discuss recent insights into pathological host-microbiota interactions and implications for disorders of the skin and distant organs. Finally, we examine how microbiota-based mechanisms can be targeted to prevent or manage skin disorders and impaired wound healing.
UR - http://www.scopus.com/inward/record.url?scp=85130917981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85130917981&partnerID=8YFLogxK
U2 - 10.1126/science.abo0693
DO - 10.1126/science.abo0693
M3 - Review article
C2 - 35617415
AN - SCOPUS:85130917981
SN - 0036-8075
VL - 376
SP - 940
EP - 945
JO - Science
JF - Science
IS - 6596
ER -