The lipolytic capacity of patients with severe and moderate thermal injury was assessed in vivo by determining the rate of clearance of chylo-microns. Twelve patients, two women and ten men, age 34 ± 12 years, had burns varying from 28% to 84% of total burn surface area (TBSA). Seven patients had an average burn size of 63% TBSA. They were hypocholesterolemic and normo-triglyceridemic during parenteral alimentation that excluded fat emulsion. But when Lyposil was infused intravenously (150 mg/Kg/hr for a period of eight hrs), plasma triglyceride (TG) levels increased. Most of the triglyceride was in the form of chylomicrons, which had a prolonged residence time in plasma. Patients with moderate thermal injury (mean % TBSA 38% ± 9%) had normal TG levels before fat infusion. When Liposyl was infused intraduodenally (170 mg/kg/hr), the plasma TG levels remained normal and the chylomicron half-life was very short. These observations suggest that patients with severe thermal injury may have reduced lipolytic capacity, especially during parenteral administration of fat emulsion.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Burn Care and Rehabilitation|
|State||Published - Jan 1 1988|
ASJC Scopus subject areas
- Emergency Medicine
- Health Professions(all)