Metabolism of catechol estrogen by human erythrocytes

G. W. Bates; C. D. Edman; J. C. Porter; P. C. MacDonald

doi:10.1210/jcem-45-5-1120

Metabolism of catechol estrogen by human erythrocytes

G. W. Bates, C. D. Edman, J. C. Porter, P. C. MacDonald

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone iri vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone by human RBC’s was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.

Original language	English (US)
Pages (from-to)	1120-1123
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	45
Issue number	5
DOIs	https://doi.org/10.1210/jcem-45-5-1120
State	Published - Nov 1977

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-45-5-1120

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AU - Bates, G. W.

AU - Edman, C. D.

AU - Porter, J. C.

AU - MacDonald, P. C.

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AB - In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone iri vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2-methoxyestrone by human RBC’s was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.

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JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

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ER -

Metabolism of catechol estrogen by human erythrocytes

Abstract

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