Abstract
Objective: Thousands of years after dietary therapy was proposed to treat seizures, how alterations in metabolism relates to epilepsy remains unclear, and metabolism-based therapies are not always effective. Methods: We consider the state of the science in metabolism-based therapies for epilepsy across the research lifecycle from basic to translational to clinical studies. Results: This analysis creates a conceptual framework for creative, rigorous, and transparent research to benefit people with epilepsy through the understanding and modification of metabolism. Interpretation: Despite intensive past efforts to evaluate metabolism-based therapies for epilepsy, distinct ways of framing a problem offer the chance to engage different mindsets and new (or newly applied) technologies. A comprehensive, creative, and inclusive problem-directed research agenda is needed, with a renewed and stringent adherence to rigor and transparency across all levels of investigation.
Original language | English (US) |
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Pages (from-to) | 1730-1737 |
Number of pages | 8 |
Journal | Annals of Clinical and Translational Neurology |
Volume | 8 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2021 |
ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology