Metabolism-based therapies for epilepsy: new directions for future cures

Mackenzie Cervenka, Juan M. Pascual, Jong M. Rho, Elizabeth Thiele, Gary Yellen, Vicky Whittemore, Adam L. Hartman

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: Thousands of years after dietary therapy was proposed to treat seizures, how alterations in metabolism relates to epilepsy remains unclear, and metabolism-based therapies are not always effective. Methods: We consider the state of the science in metabolism-based therapies for epilepsy across the research lifecycle from basic to translational to clinical studies. Results: This analysis creates a conceptual framework for creative, rigorous, and transparent research to benefit people with epilepsy through the understanding and modification of metabolism. Interpretation: Despite intensive past efforts to evaluate metabolism-based therapies for epilepsy, distinct ways of framing a problem offer the chance to engage different mindsets and new (or newly applied) technologies. A comprehensive, creative, and inclusive problem-directed research agenda is needed, with a renewed and stringent adherence to rigor and transparency across all levels of investigation.

Original languageEnglish (US)
Pages (from-to)1730-1737
Number of pages8
JournalAnnals of Clinical and Translational Neurology
Issue number8
StatePublished - Aug 2021

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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