Metabolism and the control of circadian rhythms

Jared Rutter, Martin Reick, Steven L. McKnight

Research output: Contribution to journalReview articlepeer-review

336 Scopus citations


The core apparatus that regulates circadian rhythm has been extensively studied over the past five years. A looming question remains, however, regarding how this apparatus is adjusted to maintain coordination between physiology and the changing environment. The diversity of stimuli and input pathways that gain access to the circadian clock are summarized. Cellular metabolic states could serve to link physiologic perception of the environment to the circadian oscillatory apparatus. A simple model, integrating biochemical, cellular, and physiologic data, is presented to account for the connection of cellular metabolism and circadian rhythm.

Original languageEnglish (US)
Pages (from-to)307-331
Number of pages25
JournalAnnual review of biochemistry
StatePublished - 2002


  • Central circadian oscillator
  • Circadian rhythm
  • Entrainment
  • Neural activity
  • Restricted feeding
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Biochemistry


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