@article{d5dbd24dd02c4057b136f15881a430cc,
title = "Metabolic Plasticity of Neutrophils: Relevance to Pathogen Responses and Cancer",
abstract = "Neutrophils, the most abundant leukocyte population in humans, constantly patrol the body for foreign cells, including pathogens and cancer cells. Once neutrophils are activated, they engage distinct metabolic pathways to fulfill their specialized antipathogen functions. In this review, we examine current research on the metabolism of neutrophil differentiation and antipathogen responses. We also discuss how tumor-associated neutrophils (TANs) can be educated by cytokines and by the nutrient-restrictive milieu of the tumor microenvironment (TME) to suppress antitumor immunity, promote cancer progression, and contribute to biological heterogeneity among tumors. Last, we discuss the clinical implications of circulating neutrophils and infiltrating TANs and consider how targeting TAN metabolism may synergize with cancer immunotherapy.",
keywords = "immunotherapy, metabolism, metastasis, neutrophils, tumor microenvironment",
author = "Thomas Rogers and DeBerardinis, {Ralph J.}",
note = "Funding Information: We thank Jessica Moreland and Jessica Hook for helpful discussions on neutrophil biology. We also thank our funding sources: National Cancer Institute (NCI) Pre to Postdoctoral Fellow Transition Award (K00CA212230) to T.J.R. and NCI R35 Outstanding Investigator Award (R35CA22044901) to R.J.D. R.J.D. is also supported by the Howard Hughes Medical Institute. R.J.D. is a scientific advisor for Agios Pharmaceuticals and Vida Ventures. T.JR has no competing interests to declare. Funding Information: We thank Jessica Moreland and Jessica Hook for helpful discussions on neutrophil biology. We also thank our funding sources: National Cancer Institute ( NCI) Pre to Postdoctoral Fellow Transition Award ( K00CA212230 ) to T.J.R. and NCI R35 Outstanding Investigator Award ( R35CA22044901 ) to R.J.D. R.J.D. is also supported by the Howard Hughes Medical Institute . Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",
year = "2021",
month = aug,
doi = "10.1016/j.trecan.2021.04.007",
language = "English (US)",
volume = "7",
pages = "700--713",
journal = "Trends in Cancer",
issn = "2405-8033",
publisher = "Cell Press",
number = "8",
}