Metabolic influences on RNA biology and translation

Chien Der Lee; Benjamin P. Tu

doi:10.1080/10409238.2017.1283294

Metabolic influences on RNA biology and translation

Chien Der Lee, Benjamin P. Tu

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Protein translation is one of the most energetically demanding processes for a cell to undertake. Changes in the nutrient environment may result in conditions that cannot support the rates of translation required for cell proliferation. As such, a cell must monitor its metabolic state to determine which mRNAs to translate into protein. How the various RNA species that participate in translation might relay information about metabolic state to regulate this process is not well understood. In this review, we discuss emerging examples of the influence of metabolism on aspects of RNA biology. We discuss how metabolic state impacts the localization and fate of different RNA species, as well as how nutrient cues can impact post-transcriptional modifications of RNA to regulate their functions in the control of translation.

Original language	English (US)
Pages (from-to)	176-184
Number of pages	9
Journal	Critical reviews in biochemistry and molecular biology
Volume	52
Issue number	2
DOIs	https://doi.org/10.1080/10409238.2017.1283294
State	Published - Mar 4 2017

Keywords

RNA modification
RNA quality control
RNA-protein granules
metabolism
nutrient sensing

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1080/10409238.2017.1283294

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abstract = "Protein translation is one of the most energetically demanding processes for a cell to undertake. Changes in the nutrient environment may result in conditions that cannot support the rates of translation required for cell proliferation. As such, a cell must monitor its metabolic state to determine which mRNAs to translate into protein. How the various RNA species that participate in translation might relay information about metabolic state to regulate this process is not well understood. In this review, we discuss emerging examples of the influence of metabolism on aspects of RNA biology. We discuss how metabolic state impacts the localization and fate of different RNA species, as well as how nutrient cues can impact post-transcriptional modifications of RNA to regulate their functions in the control of translation.",

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AU - Tu, Benjamin P.

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AB - Protein translation is one of the most energetically demanding processes for a cell to undertake. Changes in the nutrient environment may result in conditions that cannot support the rates of translation required for cell proliferation. As such, a cell must monitor its metabolic state to determine which mRNAs to translate into protein. How the various RNA species that participate in translation might relay information about metabolic state to regulate this process is not well understood. In this review, we discuss emerging examples of the influence of metabolism on aspects of RNA biology. We discuss how metabolic state impacts the localization and fate of different RNA species, as well as how nutrient cues can impact post-transcriptional modifications of RNA to regulate their functions in the control of translation.

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KW - RNA quality control

KW - RNA-protein granules

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Metabolic influences on RNA biology and translation

Abstract

Keywords

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