Metabolic flexibility during sleep

Simeng Zhang, Yoshiaki Tanaka, Asuka Ishihara, Akiko Uchizawa, Insung Park, Kaito Iwayama, Hitomi Ogata, Katsuhiko Yajima, Naomi Omi, Makoto Satoh, Masashi Yanagisawa, Hiroyuki Sagayama, Kumpei Tokuyama

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.

Original languageEnglish (US)
Article number17849
JournalScientific reports
Issue number1
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • General


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