TY - JOUR
T1 - Metabolic effects of thiazide and 1,25-(OH)2 vitamin D in postmenopausal osteoporosis
AU - Sakhaee, K.
AU - Zisman, A.
AU - Poindexter, J. R.
AU - Zerwekh, J. E.
AU - Pak, C. Y C
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1993/7
Y1 - 1993/7
N2 - It was previously shown that the stimulation of intestinal calcium absorption by exogenous 25-hydroxyvitamin D (25-OHD) in postmenopausal women with osteoporosis was attenuated when thiazide was added, probably due to the suppression of endogenous synthesis of 1,25-(OH)2 vitamin D (1,25-(OH)2D). To test whether the above attenuation could be averted if exogenous 1,25-(OH)2D replaced 25-OHD, 10 women with postmenopausal osteoporosis participated in a three-phase study comprising control (pretreatment), treatment with 1,25-(OH)2D 0.5 μg/day for 4 weeks, and combined 1,25-(OH)2D and trichlormethiazide (TZ) 2 mg/day for 4 weeks. The 1,25-(OH)2D treatment significantly increased serum 1,25-(OH)2D from 60±7.2 (SD) to 154±48 pmol/1, fractional intestinal calcium absorption (α) from 0.386 ±0.055 to 0.613±0.081, and urinary calcium from 3.7±0.8 to 6.6±1.9 mmol/day. Addition of TZ significantly reduced urinary calcium from 6.6±1.9 to 4.8±1.3 mmol/day, without changing α (0.613±0.081 to 0.584±0.070), serum calcium or 1,25-(OH)2D (154±48 to 154±38 pmol/1). Thus, estimated calcium balance (absorbed minus urinary calcium, increased marginally to +5.6 mmol/day on 1,25-(OH)2D alone (p=0.028) and significantly to +6.8 mmol/day on 1,25-(OH)2D+TZ, from the control value of +4.0 mmol/day. Seven patients who were treated long-term with combined 1,25-(OH)2D and TZ for 11-29 months maintained their a (0.593±0.099) and a marginally more positive estimated calcium balance (+6.4 mmol/day, p=0.025 from the control phase). Moreover, there was a stability of bone density of radial shaft, femoral neck, and lumbar spine. In conclusion, when exogenous 1,25-(OH)2D is provided, TZ does not lower serum 1,25-(OH)2D and α in patients with postmenopausal osteoporosis. Thus, the hypocalciuric action of TZ may lead to improved calcium balance and may potentially attenuate further bone loss.
AB - It was previously shown that the stimulation of intestinal calcium absorption by exogenous 25-hydroxyvitamin D (25-OHD) in postmenopausal women with osteoporosis was attenuated when thiazide was added, probably due to the suppression of endogenous synthesis of 1,25-(OH)2 vitamin D (1,25-(OH)2D). To test whether the above attenuation could be averted if exogenous 1,25-(OH)2D replaced 25-OHD, 10 women with postmenopausal osteoporosis participated in a three-phase study comprising control (pretreatment), treatment with 1,25-(OH)2D 0.5 μg/day for 4 weeks, and combined 1,25-(OH)2D and trichlormethiazide (TZ) 2 mg/day for 4 weeks. The 1,25-(OH)2D treatment significantly increased serum 1,25-(OH)2D from 60±7.2 (SD) to 154±48 pmol/1, fractional intestinal calcium absorption (α) from 0.386 ±0.055 to 0.613±0.081, and urinary calcium from 3.7±0.8 to 6.6±1.9 mmol/day. Addition of TZ significantly reduced urinary calcium from 6.6±1.9 to 4.8±1.3 mmol/day, without changing α (0.613±0.081 to 0.584±0.070), serum calcium or 1,25-(OH)2D (154±48 to 154±38 pmol/1). Thus, estimated calcium balance (absorbed minus urinary calcium, increased marginally to +5.6 mmol/day on 1,25-(OH)2D alone (p=0.028) and significantly to +6.8 mmol/day on 1,25-(OH)2D+TZ, from the control value of +4.0 mmol/day. Seven patients who were treated long-term with combined 1,25-(OH)2D and TZ for 11-29 months maintained their a (0.593±0.099) and a marginally more positive estimated calcium balance (+6.4 mmol/day, p=0.025 from the control phase). Moreover, there was a stability of bone density of radial shaft, femoral neck, and lumbar spine. In conclusion, when exogenous 1,25-(OH)2D is provided, TZ does not lower serum 1,25-(OH)2D and α in patients with postmenopausal osteoporosis. Thus, the hypocalciuric action of TZ may lead to improved calcium balance and may potentially attenuate further bone loss.
KW - 1,25-(OH)D
KW - Osteoporosis
KW - Positive calcium balance
KW - Thiazide
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U2 - 10.1007/BF01623678
DO - 10.1007/BF01623678
M3 - Article
C2 - 8338977
AN - SCOPUS:0027267045
SN - 0937-941X
VL - 3
SP - 209
EP - 214
JO - Osteoporosis International
JF - Osteoporosis International
IS - 4
ER -