Metabolic cycles as an underlying basis of biological oscillations

Research output: Contribution to journalReview articlepeer-review

174 Scopus citations


The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.

Original languageEnglish (US)
Pages (from-to)696-701
Number of pages6
JournalNature Reviews Molecular Cell Biology
Issue number9
StatePublished - Sep 19 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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