Metabolic checkpoint of ferroptosis resistance

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6 Scopus citations


The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc inhibitor-induced ferroptosis by activating pyruvate oxidation, thereby promoting fatty acid synthesis and subsequent lipid peroxidation. In contrast, the upregulation of pyruvate dehydrogenase kinase 4 (PDK4) switches into a ferroptosis-resistant state in pancreatic cancer cells.

Original languageEnglish (US)
Article number1901558
JournalMolecular and Cellular Oncology
Issue number3
StatePublished - 2021


  • Ferroptosis
  • fatty acid synthesis
  • metabolic basis
  • pancreatic cancer
  • pyruvate oxidation

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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