Membrane-Induced Technique for the Management of Combined Soft Tissue and Osseous Defects

Ryan Pereira, William C. Perry, Peter A. Crisologo, Michael D. Liette, Bryan Hall, Shawkat Ghazal Hafez Hassn, Suhail Masadeh

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The induced membrane technique is a simple, effective, and reproducible treatment method for segmental bone defects. It is a 2-stage approach that requires eventual autologous bone graft to manage the deficit. The first stage requires debridement of all nonviable tissue while preserving a healthy soft tissue envelope. A polymethylmethacrylate is implanted between the osseous segments to maintain length. The osseous defect can be stabilized internally or externally. During the second stage, a vascularized induced membrane is formed and produces multiple growth factors. The induced membrane technique is a valuable option for limb salvage in cases of segmental bone defects.

Original languageEnglish (US)
Pages (from-to)99-110
Number of pages12
JournalClinics in Podiatric Medicine and Surgery
Issue number1
StatePublished - Jan 2021
Externally publishedYes


  • Bone defect
  • Induced membrane
  • Masquelet technique

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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