Meibomian gland function and the tear lipid layer

James P McCulley; Ward E. Shine

doi:10.1016/S1542-0124(12)70138-6

Meibomian gland function and the tear lipid layer

James P McCulley, Ward E. Shine

Research output: Contribution to journal › Article › peer-review

176 Scopus citations

Abstract

The meibomian glands of the lid produce a lipid material whose synthesis is dependent on neuronal, hormonal, and vascular factors. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier and must remain functional after a blink. To satisfy these requirements, the meibomian lipids have a specific composition. Even after delivery it may be modified by lipases produced by ocular bacteria, and modifications in the lipid components can lead to unique disease states. For example, bacteria may degrade lipids, producing an unstable tear film and irritating free fatty acids; and hormonal imbalances may alter lipid profiles to destabilize the tear film and produce evaporative dry eye.

Original language	English (US)
Pages (from-to)	97-106
Number of pages	10
Journal	Ocular Surface
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/S1542-0124(12)70138-6
State	Published - Jul 2003

Keywords

Chronic blepharitis
Dry eye
Lipids
Meibomian gland

ASJC Scopus subject areas

Ophthalmology

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10.1016/S1542-0124(12)70138-6

Cite this

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abstract = "The meibomian glands of the lid produce a lipid material whose synthesis is dependent on neuronal, hormonal, and vascular factors. This lipid material is fluid, spreads easily, is a surfactant as well as an aqueous barrier and must remain functional after a blink. To satisfy these requirements, the meibomian lipids have a specific composition. Even after delivery it may be modified by lipases produced by ocular bacteria, and modifications in the lipid components can lead to unique disease states. For example, bacteria may degrade lipids, producing an unstable tear film and irritating free fatty acids; and hormonal imbalances may alter lipid profiles to destabilize the tear film and produce evaporative dry eye.",

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AU - Shine, Ward E.

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Meibomian gland function and the tear lipid layer

Abstract

Keywords

ASJC Scopus subject areas

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