Medikamentöse therapie von hirntumoren

Chemotherapy has become part of the standard treatment for many brain tumors. It plays an important role in the therapy oft the most common brain tumors, the gliomas. Several ongoing studies investigate the prognostic and therapeutic relevance of different molecular markers in glioma therapy, such as the LOH 1p/19q status or the presence of isocitrate dehydrogenase mutations and MGMT promoter methylation. New therapeutic approaches from immunotherapy, virotherapy, and inhibition of angiogenesis are currently under investigation in preclinical and clinical studies. For the more seldom-occurring brain tumors, such as pilocytic astrocytomas, ependymomas and medulloblastomas, large studies concerning the relevance of chemotherapy are lacking. However, chemotherapy plays a key role in the treatment of primary CNS lymphomas.