Mechanosensitivity of gramicidin A channels in semispherical bilayer membranes at constant tension

V. S. Markin, V. G. Shlenskiǐ, S. A. Saimon, D. D. Benos, I. I. Ismailov

Research output: Contribution to journalArticlepeer-review

Abstract

Mechanoelectrical transduction in gramicidin A channels was studied in macroscopic planar lipid bilayer membranes bulged at constant tension. We found a supralinear increase in the single channel activity, which was proportional to the square of membrane radius but could not be accounted for by the increase in membrane surface area or by recruitment of new channels. When being extrapolated to biological membranes, these observations may suggest that the activity of permeability of ion channels can be influenced simply by changing the shape of the membrane, with or without stretching.

Original languageEnglish (US)
Pages (from-to)1014-1018
Number of pages5
JournalBiofizika
Volume51
Issue number6
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • General Medicine

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