TY - JOUR
T1 - Mechanism of thyrotoxic periodic paralysis
AU - Lin, Shih Hua
AU - Huang, Chou Long
PY - 2012/6
Y1 - 2012/6
N2 - The pathogenesis of thyrotoxic periodic paralysis has long been thought related to increasedNa+-K + ATPase activity stimulated by thyroid hormone and/or hyperadrenergic activity and hyperinsulinemia. This mechanism alone, however, cannot adequately explain how hypokalemia occurs during acute attacks or the associated paradoxical depolarization of the resting membrane potential. Recent findings that loss of function mutations of the skeletal muscle-specific inward rectifying K + (Kir) channel, Kir2.6, associatewith thyrotoxicperiodicparalysisprovide newinsights intohowreduced outwardK + efflux in skeletal muscle, from either channel mutations or inhibition by hormones (adrenalin or insulin), can lead to a vicious cycle of hypokalemia and paradoxical depolarization, which in turn, inactivates Na + channels and causes muscle unexcitability and paralysis.
AB - The pathogenesis of thyrotoxic periodic paralysis has long been thought related to increasedNa+-K + ATPase activity stimulated by thyroid hormone and/or hyperadrenergic activity and hyperinsulinemia. This mechanism alone, however, cannot adequately explain how hypokalemia occurs during acute attacks or the associated paradoxical depolarization of the resting membrane potential. Recent findings that loss of function mutations of the skeletal muscle-specific inward rectifying K + (Kir) channel, Kir2.6, associatewith thyrotoxicperiodicparalysisprovide newinsights intohowreduced outwardK + efflux in skeletal muscle, from either channel mutations or inhibition by hormones (adrenalin or insulin), can lead to a vicious cycle of hypokalemia and paradoxical depolarization, which in turn, inactivates Na + channels and causes muscle unexcitability and paralysis.
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U2 - 10.1681/ASN.2012010046
DO - 10.1681/ASN.2012010046
M3 - Short survey
C2 - 22460532
AN - SCOPUS:84861835800
SN - 1046-6673
VL - 23
SP - 985
EP - 988
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 6
ER -