Mechanism and regulation of transcriptional elongation by RNA polymerase II

Daniel Reines, Ronald C. Conaway, Joan Weliky Conaway

Research output: Contribution to journalReview articlepeer-review

69 Scopus citations


Over the past few years, biochemical and genetic studies have shed considerable light on the structure and function of the RNA polymerase II (pol II) elongation complex and the transcription factors that control it. Novel elongation factors have been identified and their mechanisms of action characterized in increasing detail; new insights into the biological roles of elongation factors have been gained from genetic studies of the regulation of mRNA synthesis in yeast; and intriguing links between the pol II elongation machinery and the pathways of DNA repair and recombination have emerged.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalCurrent Opinion in Cell Biology
Issue number3
StatePublished - Jun 1999
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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