TY - JOUR
T1 - Mechanically Activated Ion Channels
AU - Ranade, Sanjeev S.
AU - Syeda, Ruhma
AU - Patapoutian, Ardem
N1 - Publisher Copyright:
© 2015 Elsevier Inc..
PY - 2015/9/23
Y1 - 2015/9/23
N2 - Mechanotransduction, the conversion of physical forces into biochemical signals, is essential for various physiological processes such as the conscious sensations of touch and hearing, and the unconscious sensation of blood flow. Mechanically activated (MA) ion channels have been proposed as sensors of physical force, but the identity of these channels and an understanding of how mechanical force is transduced has remained elusive. A number of recent studies on previously known ion channels along with the identification of novel MA ion channels have greatly transformed our understanding of touch and hearing in both vertebrates and invertebrates. Here, we present an updated review of eukaryotic ion channel families that have been implicated in mechanotransduction processes and evaluate the qualifications of the candidate genes according to specified criteria. We then discuss the proposed gating models for MA ion channels and highlight recent structural studies of mechanosensitive potassium channels. Mechanically activated (MA) ion channels are structurally diverse sensors required for numerous physiological processes including touch, pain, and hearing. Here, Ranade et al. review eukaryotic MA channel families, and explore the potential mechanisms of how these channels might be gated.
AB - Mechanotransduction, the conversion of physical forces into biochemical signals, is essential for various physiological processes such as the conscious sensations of touch and hearing, and the unconscious sensation of blood flow. Mechanically activated (MA) ion channels have been proposed as sensors of physical force, but the identity of these channels and an understanding of how mechanical force is transduced has remained elusive. A number of recent studies on previously known ion channels along with the identification of novel MA ion channels have greatly transformed our understanding of touch and hearing in both vertebrates and invertebrates. Here, we present an updated review of eukaryotic ion channel families that have been implicated in mechanotransduction processes and evaluate the qualifications of the candidate genes according to specified criteria. We then discuss the proposed gating models for MA ion channels and highlight recent structural studies of mechanosensitive potassium channels. Mechanically activated (MA) ion channels are structurally diverse sensors required for numerous physiological processes including touch, pain, and hearing. Here, Ranade et al. review eukaryotic MA channel families, and explore the potential mechanisms of how these channels might be gated.
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U2 - 10.1016/j.neuron.2015.08.032
DO - 10.1016/j.neuron.2015.08.032
M3 - Review article
C2 - 26402601
AN - SCOPUS:84942134031
SN - 0896-6273
VL - 87
SP - 1162
EP - 1179
JO - Neuron
JF - Neuron
IS - 6
ER -