Abstract
Objective This study described the prospective relationship between pharmacological and behavioral measures of 6-mercaptopurine (6MP)medication adherence in amultisite cohort of pediatric patients diagnosed with cancer (N=139). Methods Pharmacological measures (i.e., metabolite concentrations) assessed 6MP intake. Behavioral measures (e.g., electronic monitoring) described adherence patterns over time. Results Three metabolite profiles were identified across 15 months: one group demonstrated low levels of both metabolites (40.8%) consistent with nonadherence and/or suboptimal therapy; two other groups demonstrated metabolite clusters indicative of adequate adherence (59.2%). Those patients whose metabolite profile demonstrated low levels of both metabolites had consistently lower behavioral adherence rates. Conclusions To our knowledge, thiswas the first study to prospectively validate a pharmacological measure of medication adherence with a behavioral adherence measure in a relatively large sample of pediatric patients with cancer. Using multiple methods of adherencemeasurement could informclinical care and target patients in need of intervention.
Original language | English (US) |
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Pages (from-to) | 232-244 |
Number of pages | 13 |
Journal | Journal of pediatric psychology |
Volume | 42 |
Issue number | 2 |
DOIs | |
State | Published - 2017 |
Keywords
- Adherence
- Cancer
- Metabolites
- Metabolites
- Pediatrics
- Pharmacology
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental and Educational Psychology